Biology of N-Methylpyrrole-N-methylimidazole Hairpin Polyamide

Thermochemical studies of N-methylpyrazole and N-methylimidazole.

The 351.1 nm photoelectron spectra of the N-methyl-5-pyrazolide anion and the N-methyl-5-imidazolide anion are reported. The photoelectron spectra of both isomers display extended vibrational progressions in the X2A' ground states of the corresponding radicals that are well reproduced by Franck-Condon simulations, based on the results of B3LYP/6-311++G(d,p) calculations. The electron affinities...

Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA

A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as we...

Properties of Cu nanoparticles - poly ( N - methylpyrrole ) composites

Multiple configurations of N-methylpyrrole binding on Si„111...-7Ã7

The adsorption configurations of N-methylpyrrole on Si(111)-737 were investigated using high-resolution electron energy-loss spectroscopy, x-ray photoelectron spectroscopy ~XPS!, scanning tunneling microscopy ~STM!, and density function theory calculations. Compared to physisorbed N-methylpyrrole, chemisorbed molecules present a different vibrational feature at 2886 cm attributable to n@(Si)C-H...

N-Methylimidazole Promotes the Reaction of Homophthalic Anhydride with Imines

The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationali...